Journal: Regenerative Therapy

Article Title: Autologous angiogenic therapy with cultured mesenchymal stromal cells in platelet-rich plasma for critical limb ischemia

doi: 10.1016/j.reth.2023.09.011

Figure Lengend Snippet: Changes in ulcer size, 6-min walking distance, dorsal SPP, ankle SPP, and ABPI after cell transplantation. All three ulcers showed reduction in size after cell therapy. Six months after transplantation, absolute claudication distance improved from 206.6 m at baseline to 380.0 m, dorsal SPP increased from 32.6 mmHg to 78.3 mmHg, ankle TcPO 2 improved from 15.2 mmHg to 70.7 mmHg, And ABPI changed from 0.56 to 0.65. Abbreviations: SPP, skin perfusion pressure; TcPO 2 , transcutaneous partial oxygen pressure; ABPI, ankle brachial pressure index.

Article Snippet: The secondary endpoint was efficacy, which included the following parameters: (a) amputation-free 12 months after cell therapy; (b) rate of improvement from CLI to non-CLI stage assessed according to the Fontaine stage and Rutherford category six months after cell therapy; (c) death due to CLI 12 months after cell therapy; (d) all-cause death 12 months after cell therapy; (e) changes in ulcer size 12 months after cell therapy, pain-free walking distance in 6-min walking test six months after cell therapy, and physiological tests including ankle brachial pressure index (ABPI) (BP203RPEIII; Omron Colin, San Antonio, TX, USA) six months after cell therapy, skin perfusion pressure (SPP) (PAD4000; Kaneka, Tokyo, Japan) six months after cell therapy, and transcutaneous partial oxygen pressure (TcPO 2 ) (PO-850; Sumitomo Electric System Solutions, Tokyo, Japan)six months after cell therapy.

Techniques: Transplantation Assay